- The Eastern Quarantine Zone was the most dangerous, and was where most of the outbreak was. The western parts of the quarantine were less dangerous than the west, and had the same danger levels as the central zone.
- The Southwestern Quarantine Zone was the second most dangerous, and despite being massive in size had a high infection rate.
- The Western Quarantine Zone was the third most dangerous, but California was the odd exception for that, keeping its borders relatively safe.
- The Central Quarantine Zone was the second least dangerous, with the second-to-least number of infected.
- The Northern Quarantine Zone was the least dangerous.
The WHO, after setting up the quarantine zones, began a blockade of ports in North America, using the islands around it as a base of naval operations. The main goal was to keep the infection on the landmass, but that goal was not successful, as the outbreak did spread out of the North American Continent. In fact, by April 23rd, there were two hundred cases of the outbreak in Europe, Asia, and Africa, and spreading.
It did, however, slow the spread, and allowed the world to, for the most part, keep an eye on the outbreak. The rest of the world fell slower, meaning that the quarantine was upheld until 2027. In 2027, the quarantine was lifted, not due to the plague stopping, but because the rest of the world needed all its efforts to keep itself from collapsing. Contact was lost with the outside world in summer 2027, when the fleet keeping the quarantine in check left the Caribbean. Until then, the fleet had occasionally made land fall to check on the world, but was not too involved.